Centrosome dynamics as a source of chromosomal instability
نویسندگان
چکیده
منابع مشابه
Epstein–Barr virus particles induce centrosome amplification and chromosomal instability
Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be r...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2015
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2014.10.002